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N-acetyl-L-cysteine inhibits marble-burying behavior in mice
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نویسنده
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egashira n. ,shirakawa a. ,abe m. ,niki t. ,mishima k. ,iwasaki k. ,oishi r. ,fujiwara m.
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منبع
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journal of pharmacological sciences - 2012 - دوره : 119 - شماره : 1 - صفحه:97 -101
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چکیده
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In the present study,we examined the effect of n-acetyl-l-cysteine (nac),a glutamate-modulating agent,on marble-burying behavior in mice. fluvoxamine (30 mg/kg,p.o.) and mirtazapine (3 mg/kg,i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. similarity,nac (150 mg/kg,i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. on the other hand,the antioxidant á-tocopherol (10,30,and 100 mg/kg,p.o.) had no effect on the marble-burying behavior. these results suggest that the glutamatergic system is involved in the marble-burying behavior,and nac may be useful for treatment of ocd. © the japanese pharmacological society.
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کلیدواژه
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Marble-burying behavior; N-acetyl-L-cysteine; Obsessive-compulsive disorder
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آدرس
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department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180,japan,department of pharmacy,kyushu university hospital,3-1-1 maidashi,higashi-ku,fukuoka 812-8582, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmacy,kyushu university hospital,3-1-1 maidashi,higashi-ku,fukuoka 812-8582, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan
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Authors
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