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   Danhong inhibits oxidized low-density lipoprotein-induced immune maturation of dentritic cells via a peroxisome proliferator activated receptor γ-mediated pathway  
   
نویسنده liu h. ,wang s. ,sun a. ,huang d. ,wang w. ,zhang c. ,shi d. ,chen k. ,zou y. ,ge j.
منبع journal of pharmacological sciences - 2012 - دوره : 119 - شماره : 1 - صفحه:1 -9
چکیده    Danhong injection (dhi),a chinese materia medica standardized product extracted from radix salviae miltiorrhizae and flos carthami tinctorii,is effective in the treatment of atherosclerosis (as)-related diseases. it is widely recognized that as is a complex inflammatory disease of the arterial wall and the dendritic cells (dcs) is a major player in the pathogenesis of as via mediating atherosclerotic antigen presenting and t lymphocytes. here,we determined the effect and possible mechanism of dhi on oxidized low-density lipoprotein (ox-ldl)-induced maturation and immune function of dcs. human monocyte-derived dcs were incubated with dhi or ciglitazone and were subsequently stimulated with ox-ldl to induce maturation. similar to ciglitazone,a peroxisome proliferator activated receptor (ppar) γ agonist,dhi,could significantly reduce ox-ldl-induced expressions of mature markers,enhance the endocytotic function,and inhibit secretions of cytokine on dcs. these effects of dhi could be partly reversed by silencing the pparγ. in conclusion,dhi could inhibit ox-ldl-induced maturation of dcs partly through activating a pparγ-mediated signaling pathway. © the japanese pharmacological society.
کلیدواژه Atherosclerosis; Danhong injection; Dendritic cell; Peroxisome proliferator activated receptor (PPAR) γ
آدرس shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, xiyuan hospital,china academy of chinese medical sciences,beijing 100091, China, xiyuan hospital,china academy of chinese medical sciences,beijing 100091, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China, shanghai institute of cardiovascular diseases,zhongshan hospital,fudan university,180 feng lin road,shanghai 200032, China
 
     
   
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