|
|
|
|
Inhibitory effect of cibenzoline on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes
|
|
|
|
|
|
|
|
نویسنده
|
yamakawa t. ,watanabe y. ,watanabe h. ,kimura j.
|
|
منبع
|
journal of pharmacological sciences - 2012 - دوره : 120 - شماره : 1 - صفحه:59 -62
|
|
چکیده
|
The effect of cibenzoline,a class i antiarrhythmic drug,on na +/ca2+ exchange current (incx) was investigated using the patch-clamp method. cibenzoline inhibited the bi-directional i ncx in a concentration-dependent manner. the ic50 values of cibenzoline for the outward and inward components of incx were 77 and 84 μm,respectively,with hill coefficients of 1. intracellular application of trypsin via the pipette solution did not change the inhibitory effect of cibenzoline. the inhibitory effect of cibenzoline on incx at pho 6.5 was smaller than those at pho 7.4 and ph o 8.2. we conclude that cibenzoline inhibits incx in supra-therapeutic concentrations. © the japanese pharmacological society.
|
|
کلیدواژه
|
Antiarrhythmic drug; Cibenzoline; Na+/Ca2+ exchange (NCX)
|
|
آدرس
|
department of health science,hamamatsu university school of medicine,1-20-1 handa-yama,hamamatsu 431-3192,japan,department of clinical pharmacology,hamamatsu university school of medicine,1-20-1 handa-yama,hamamatsu 431-3192, Japan, department of health science,hamamatsu university school of medicine,1-20-1 handa-yama,hamamatsu 431-3192, Japan, department of clinical pharmacology,hamamatsu university school of medicine,1-20-1 handa-yama,hamamatsu 431-3192, Japan, department of pharmacology,school of medicine,fukushima medical university,fukushima 960-1295, Japan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|