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Adrenergic stimulation - Released histamine taken-up in adrenergic nerves induces endothelium-dependent vasodilation in rat mesenteric resistance arteries
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نویسنده
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haruki y. ,takatori s. ,hattori s. ,zamami y. ,koyama t. ,tangsucharit p. ,kawasaki h.
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منبع
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journal of pharmacological sciences - 2012 - دوره : 118 - شماره : 4 - صفحه:537 -542
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چکیده
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The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (pns) to induce vascular responses. in rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene - related peptide (cgrp)ergic vasodilation and with active tone,pns (1-4 hz) induced only adrenergic nerve - mediated vasoconstriction. histamine treatment for 20 min induced pns-induced vasoconstriction followed by vasodilation without affecting cgrp-induced vasodilation. chlorpheniramine,guanethidine,combination of histamine and desipramine,and endothelium-removal abolished pns-induced vasodilation in histamine-treated preparations. these results suggest that histamine taken up by and released from adrenergic nerves by pns causes endothelium-dependent vasodilation in rat mesenteric arteries. © the japanese pharmacological society.
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کلیدواژه
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Histamine; Perivascular adrenergic nerve; Rat mesenteric artery
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آدرس
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department of clinical pharmaceutical science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan, department of clinical pharmaceutical science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan, department of clinical pharmaceutical science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan, department of molecular design for medicine,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan, department of pharmaceutical care and health science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,1-1-1 tsushima-naka,okayama 700-8530, Japan, department of clinical pharmaceutical science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan, department of clinical pharmaceutical science,graduate school of medicine,dentistry and pharmaceutical sciences,okayama university,okayama 700-8530, Japan
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Authors
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