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Comparison of high and low affinity serotonin 1A receptors by PET in vivo in nonhuman primates
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نویسنده
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kumar j.s.d. ,milak m.s. ,majo v.j. ,prabhakaran j. ,mali p. ,savenkova l. ,mann j.j. ,parsey r.v.
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منبع
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journal of pharmacological sciences - 2012 - دوره : 120 - شماره : 3 - صفحه:254 -257
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چکیده
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Serotonin (5-ht) 1a receptors exist in high and low affinity states. agonist ligands bind preferentially to the high affinity state receptors,providing a more functionally relevant measure than antagonist binding. we now report comparison of 5-ht1a binding in vivo using both [ 11c]cumi-101 (agonist) and [11c]way100635 (antagonist) in nonhuman primates. pet studies show that both tracers bind to known 5-ht 1a receptor (5-ht1ar)-rich regions of baboon brain. the binding (bpf) of [11c]cumi-101 was lower on an average of 55% across the regions of interest (rois) compared to [11c]way100635. this ratio is consistent with the in vitro binding data of agonist and antagonist 5-ht1ar ligands previously reported. © the japanese pharmacological society.
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کلیدواژه
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5-HT1A receptor (5-HT1AR); Brain imaging; Positron emission tomography
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آدرس
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department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032,united states,new york state psychiatric institute,new york,ny 10032, United States, department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032,united states,new york state psychiatric institute,new york,ny 10032, United States, department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032, United States, department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032, United States, new york state psychiatric institute,new york,ny 10032, United States, department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032, United States, department of psychiatry,columbia university,college of physicians and surgeons,new york,ny 10032,united states,department of radiology,columbia university,college of physicians and surgeons,new york,ny 10032,united states,new york state psychiatric institute,new york,ny 10032, United States, department of psychiatry and behavioral medicine,stony brook university,stony brook,ny 11794, United States
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Authors
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