Prevention of topical surfactant-induced itch-related responses by Chlorogenic acid through the inhibition of increased histamine production in the epidermis

Effects of chlorogenic acid on surfactant-induced itching were studied in mice. topical application of sodium laurate increased hind-paw scratching,an itch-related response,2 h after application,which was inhibited by topical post-treatment with chlorogenic acid. sodium laurate increased the histamine content and 53-kda l-histidine decarboxylase in the epidermis,which were also inhibited by post-treatment with chlorogenic acid. these results suggest that topical chlorogenic acid is effective in the prevention of itching induced by anionic surfactants. the inhibitory activity of chlorogenic acid may be due to the inhibition of an increase in histamine in the epidermis. © the japanese pharmacological society.