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Antitumor effect of bevacizumab in a xenograft model of canine hemangiopericytoma
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نویسنده
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michishita m. ,uto t. ,nakazawa r. ,yoshimura h. ,ogihara k. ,naya y. ,tajima t. ,azakami d. ,kishikawa s. ,arai t. ,takahashi k.
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منبع
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journal of pharmacological sciences - 2013 - دوره : 121 - شماره : 4 - صفحه:339 -342
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چکیده
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Canine hemangiopericytoma (chp) is characterized by frequent local recurrence and increased invasiveness. vascular endothelial growth factor (vegf) is a key regulator of angiogenesis in tumors. the aim of the present study was to investigate the effect of a single dose of bevacizumab on a xenograft model of chp. vegf protein was secreted from cultured chp cells and interacted with bevacizumab. bevacizumab treatment suppressed tumor growth by inhibiting tumor angiogenesis,whereas no significant differences were observed in the proliferation index and apoptosis rates of treated and untreated mice. thus,bevacizumab had antitumor effects in a xenograft model of chp. © the japanese pharmacological society.
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کلیدواژه
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Bevacizumab; Canine hemangiopericytoma; Vascular endothelial growth factor (VEGF)
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آدرس
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department of veterinary pathology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of veterinary pathology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of veterinary pathology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of veterinary pathology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of pathology,school of life and environmental science,azabu university,1-17-71 fuchinobe,chuo-ku,sagamihara,kanagawa 252-5201, Japan, department of pathology,school of life and environmental science,azabu university,1-17-71 fuchinobe,chuo-ku,sagamihara,kanagawa 252-5201, Japan, department of veterinary pharmacology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of veterinary nursing,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of pathology,school of life and environmental science,azabu university,1-17-71 fuchinobe,chuo-ku,sagamihara,kanagawa 252-5201, Japan, department of veterinary biochemistry,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan, department of veterinary pathology,nippon veterinary and life science university,1-7-1 kyonan-cho,musashino,tokyo 180-8602, Japan
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Authors
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