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Neu2000 potentiates a kainate response in mouse cortical neurons
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نویسنده
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noh j. ,chung j.-m.
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منبع
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journal of pharmacological sciences - 2013 - دوره : 122 - شماره : 2 - صفحه:149 -152
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چکیده
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Neu2000,acting as an antioxidant with n-methyl-d-aspartate-receptor antagonism,demonstrates excellent protection against ischemic insults in rodents. in this study,we report that neu2000 also dramatically enhances the activity of kainate (ka) receptors. neu2000 noncompetitively and reversibly potentiated ka-evoked responses in a voltage-independent manner,mainly by increasing the open probability of ka receptor channels. © 2013 the japanese pharmacological society.
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کلیدواژه
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Kainic acid; Noise analysis; Voltage-clamp
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آدرس
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department of brain and cognitive sciences,ewha womans university,daehyun-dong,seodaemun-gu,seoul 120-750,south korea,deparment of science education,dankook university,#152 jukjeon-ro,suji-gu,yongin-si,gyeonggi-do 448-701, South Korea, department of brain and cognitive sciences,ewha womans university,daehyun-dong,seodaemun-gu,seoul 120-750, South Korea
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Authors
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