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Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice
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نویسنده
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li b. ,tang f. ,wang l. ,liu l. ,zhao j. ,zhou y. ,wang y. ,song y. ,li y. ,cui r.
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منبع
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journal of pharmacological sciences - 2013 - دوره : 123 - شماره : 2 - صفحه:195 -198
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چکیده
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We investigated the anticonvulsant effect of acute fuzi total alkaloid (fta) in seizure induced by the gabaa-receptor antagonist pentylenetetrazole (ptz). fta significantly increased the seizure latency and decreased the mortality in ptz-treated mice. administration of ptz increased c-fos expression in the hippocampus,medial prefrontal cortex,and piriform cortex; and this ptz-induced effect was inhibited by fta in a dose-dependent manner. furthermore,the effects of fta on ptz-induced seizure and c-fos expression were reversed by the gabaa/benzodiazepine receptor-selective antagonist flumazenil. these findings suggest that the anticonvulsant effects of fta may be related to modulation of gaba a-benzodiazepine receptor complex. © the japanese pharmacological society.
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کلیدواژه
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c-Fos; Pentylenetetrazole; Seizure
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آدرس
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national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024, China, national engineering laboratory for druggable gene and protein screening,school of life sciences,northeast normal university,changchun 130024,china,jilin key laboratory of animal resource conservation and utilization,school of life sciences,northeast normal university,changchun 130024, China
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Authors
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