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The effect of lamotrigine on Nav1.4 voltage-gated sodium channels
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نویسنده
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nakatani y. ,masuko h. ,amano t.
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منبع
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journal of pharmacological sciences - 2013 - دوره : 123 - شماره : 2 - صفحه:203 -206
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چکیده
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Lamotrigine (ltg) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that ltg targets voltage-dependent sodium channels (vgscs). in this study,we investigated the effect of ltg on the nav1.4 na+ current using hek293 cells expressing mouse nav1.4 vgscs. by the treatment of ltg,na v1.4 na+ current was inhibited in a dose-dependent manner. moreover,100 μm ltg decreased nav1.4 na+ current around 40% and shifted the v1/2 of the inactivation curve to the hyperpolarization side by 20.96 mv. these findings suggest that ltg inhibits nav1.4 na+ current and modifies the kinetics of the inactivated state. © the japanese pharmacological society.
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کلیدواژه
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Lamotrigine; Nav1.4; Voltage-clamp
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آدرس
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department of pharmacotherapeutics,school of pharmacy,international university of health and welfare,2600-1 kitakanemaru,ohtawara,tochigi 324-8501, Japan, department of pharmacotherapeutics,school of pharmacy,international university of health and welfare,2600-1 kitakanemaru,ohtawara,tochigi 324-8501, Japan, department of pharmacotherapeutics,school of pharmacy,international university of health and welfare,2600-1 kitakanemaru,ohtawara,tochigi 324-8501, Japan
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Authors
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