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Glycyrrhetinic acid reverses the lipopolysaccharide-induced hypocontractility to noradrenaline in rat aorta: Implications to septic shock
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نویسنده
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muller b. ,aparin p.g. ,stoclet j.-c. ,kleschyov a.l.
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منبع
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journal of pharmacological sciences - 2014 - دوره : 125 - شماره : 4 - صفحه:422 -425
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چکیده
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Septic shock and associated vascular hyporeactivity to vasoconstrictor agonists remain a major problem of critical care medicine. here we report that glycyrrhetinic acid (ga),the active component of licorice,effectively restores vascular contractility in the model of lipo-polysaccharide (lps)-treated rat aorta. ga was as effective as the no synthase inhibitor ng-nitroarginine methylester. ga did not affect the vascular no levels (measured by epr spin trapping) and relaxations to l-arginine in lps-treated rings as well as relaxation to s-nitroso-n-acetylpenicillamine in control rings. thus,ga may represent an interesting alternative to no synthase inhibitors in sepsis-associated vascular dysfunction. © the japanese pharmacological society.
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کلیدواژه
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Glycyrrhetinic acid; Lipopolysaccharide; Septic shock
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آدرس
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umr cnrs 7213,laboratory of biophotonics and pharmacology,university of strasbourg,illkirch,67401,france,inserm u1045,center for cardio-thoracic research,university of bordeaux,bordeaux,33076, France, laboratory of carbohydrate vaccines,national research center for immunology,moscow,115478, Russian Federation, umr cnrs 7213,laboratory of biophotonics and pharmacology,university of strasbourg,illkirch,67401, France, umr cnrs 7213,laboratory of biophotonics and pharmacology,university of strasbourg,illkirch,67401,france,second medical department,university medical center,johannes-gutenberg university,mainz,55131, Germany
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Authors
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