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Dopaminergic hyperactivity accompanied by hyperlocomotion in C57BL/6J-bgJ/bgJ (beige-J) mice
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نویسنده
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mori t. ,funada m. ,tsuda y. ,maeda j. ,uchida m. ,suzuki t.
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منبع
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journal of pharmacological sciences - 2014 - دوره : 125 - شماره : 2 - صفحه:233 -236
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چکیده
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Genetic factors affect locomotor activity,which mainly depends on the activation of dopaminergic systems. c57bl/6j-bgjbgj (beige-j) mice,which exhibit deficiencies in immunological function,show behavioral hyperactivity. the present study was designed to investigate the locomotor activity of beige-j mice accompanied by a change in the dopaminergic system. beige-j mice showed higher locomotor activity and dopamine turnover,whereas splenectomy reduced this hyperlocomotion and dopamine turnover. these results suggest that beige-j mice could be suitable as an experimental animal model for investigating hyperactivation of the dopaminergic system,and the spleen may contribute to the susceptibility of dopaminergic systems to activation. © the japanese pharmacological society.
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کلیدواژه
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Beige-J mouse; Dopamine; Splenectomy
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آدرس
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department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan, department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan, department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan, department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan, department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan, department of toxicology,hoshi university school of pharmacy and pharmaceutical sciences,tokyo 142-8501, Japan
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Authors
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