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Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior
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نویسنده
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nishinaka t. ,yamashita t. ,nakamoto k. ,kasuya f. ,tokuyama s.
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منبع
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journal of pharmacological sciences - 2014 - دوره : 125 - شماره : 1 - صفحه:112 -115
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چکیده
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The functional role of brain g protein-coupled receptor 40 (gpr40) remains unclear. we investigated gpr40 signaling in depression-related behavior in mice via the forced swim test. a repeated but not a single intracerebroventricular administration of the gpr40 agonist,gw9508,reduced the duration of immobility behavior. moreover,the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. these results suggested that brain gpr40 signaling may regulate depression-related behavior. © the japanese pharmacological society.
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کلیدواژه
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Depression; Free fatty acid; G protein-coupled receptor 40
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آدرس
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department of clinical pharmacy,kobe gakuin university,1-1-3 minatojima,chuo-ku,kobe 650-8586, Japan, biochemical toxicology laboratory,school of pharmaceutical sciences,kobe gakuin university,1-1-3 minatojima,chuo-ku,kobe 650-8586, Japan, department of clinical pharmacy,kobe gakuin university,1-1-3 minatojima,chuo-ku,kobe 650-8586, Japan, biochemical toxicology laboratory,school of pharmaceutical sciences,kobe gakuin university,1-1-3 minatojima,chuo-ku,kobe 650-8586, Japan, department of clinical pharmacy,kobe gakuin university,1-1-3 minatojima,chuo-ku,kobe 650-8586, Japan
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Authors
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