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Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents
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نویسنده
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akagi t. ,matsumura y. ,yasui m. ,minami e. ,inoue h. ,masuda t. ,tozaki-saitoh h. ,tamura t. ,mizumura k. ,tsuda m. ,kiyama h. ,inoue k.
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منبع
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journal of pharmacological sciences - 2014 - دوره : 126 - شماره : 2 - صفحه:172 -176
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چکیده
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We investigated the role of interferon regulatory factor 8 (irf8) in a model of chronic pain in which repeated cold stress (rcs) exposure produces tactile allodynia. rcs exposure produced a decrease in paw withdrawal threshold (pwt) to mechanical stimulation. spinal microglia of rcs-exposed mice were morphologically activated. expression of irf8 was significantly increased in the spinal cord of rcs-exposed mice and was localized in microglia. irf8-knockout mice failed to show the rcs-induced decrease in pwt. thus,rcs exposure activates spinal microglia and upregulation of irf8 in these cells is involved in the development of tactile allodynia after rcs exposure. © the japanese pharmacological society.
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کلیدواژه
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Interferon regulatory factor-8; Microglia; Repeated cold stress
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آدرس
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department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of functional anatomy and neuroscience,nagoya university graduate school of medicine,65 tsurumaicho,showaku,nagoya,446-8550,japan,core research for evolution science and technology,japan science and technology agency,tokyo,102-0076, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582,japan,core research for evolution science and technology,japan science and technology agency,tokyo,102-0076, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of immunology,yokohama city university graduate school of medicine,yokohama,236-0004, Japan, department of physical therapy,college of life and health sciences,chubu university,kasugai, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582,japan,department of life innovation,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582, Japan, department of functional anatomy and neuroscience,nagoya university graduate school of medicine,65 tsurumaicho,showaku,nagoya,446-8550,japan,core research for evolution science and technology,japan science and technology agency,tokyo,102-0076, Japan, department of molecular and system pharmacology,graduate school of pharmaceutical sciences,kyushu university,3-1-1 maidashi,higashi-ku,fukuoka,fukuoka,812-8582,japan,core research for evolution science and technology,japan science and technology agency,tokyo,102-0076, Japan
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