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Neuritogenic activity of trichostatin a in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction
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نویسنده
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koriyama y. ,sugitani k. ,ogai k. ,kato s.
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منبع
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journal of pharmacological sciences - 2014 - دوره : 124 - شماره : 1 - صفحه:112 -116
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چکیده
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Like other cns neurons,mature retinal ganglion cells (rgcs) cannot regenerate their axons after nerve injury due to loss of regenerative capacity. one of the reasons why they lose their capacity seems to be a dramatic shift in gene expression of rgcs under epigenetic modulation. in here,we found that levels of histone h3 lysine 9 acetylation decreased after birth in rgcs. this decrease showed good correlation with restriction of retinoic acid receptor β (rarβ) expression in rgcs after birth. furthermore,we demonstrated that a histone deacetylase inhibitor,trichostatin a,induced axonal regeneration of adult rat rgcs through rarβ induction. © the japanese pharmacological society.
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کلیدواژه
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CNS regeneration; Epigenetic modulation; Retinoic acid receptor β (RARβ)
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آدرس
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department of molecular neurobiology,graduate school of medicine,kanazawa university,13-1 takaramachi,kanazawa 920-8640, Japan, division of health sciences,graduate school of medical science,kanazawa university,5-11-80 kodatsuno,kanazawa 920-0942, Japan, department of molecular neurobiology,graduate school of medicine,kanazawa university,13-1 takaramachi,kanazawa 920-8640,japan,wellness promotion science center,institute of medical,pharmaceutical and health sciences,kanazawa university,5-11-80 kodatsuno,kanazawa 920-0942, Japan, department of molecular neurobiology,graduate school of medicine,kanazawa university,13-1 takaramachi,kanazawa 920-8640, Japan
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Authors
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