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Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest
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نویسنده
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chen w. ,liu y. ,li m. ,mao j. ,zhang l. ,huang r. ,jin x. ,ye l.
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منبع
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journal of pharmacological sciences - 2015 - دوره : 127 - شماره : 3 - صفحه:332 -338
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چکیده
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Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in traditional chinese medicine. the α-pinene is a natural compound isolated from pine needle oil which has been shown anti-cancer activity. in previous study,we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma bel-7402 cells. in this study,we investigate the inhibition of αpinene on hepatoma carcinoma bel-7402 cells in vitro and in vivo and further explore the mechanism. the results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo,chk1 and chk2 levels were upregulated,cyclin b,cdc25 and cdk1 levels were downregulated. © 2015 japanese pharmacological society. production and hosting by elsevier b.v. all rights reserved.
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کلیدواژه
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BEL-7402 cells; In vitro and in vivo; Liver cancer; Mechanism; α-Pinene
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آدرس
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school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, school of basic courses,guangdong pharmaceutical university,guangzhou,guangdong,510006, China, medicinal chemistry department,guangdong pharmaceutical university,guangzhou higher education mega center guangzhou,guangzhou,guangdong,510006, China
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Authors
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