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Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements
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نویسنده
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aoki y. ,nishizawa d. ,hasegawa j. ,kasai s. ,yoshida k. ,koukita y. ,ichinohe t. ,nagashima m. ,katoh r. ,satoh y. ,tagami m. ,hayashida m. ,fukuda k.-i. ,ikeda k.
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منبع
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journal of pharmacological sciences - 2015 - دوره : 127 - شماره : 3 - صفحه:391 -393
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چکیده
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An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily c member 3 (trpc3) gene was suggested by our previous genome-wide association study. to verify this association,we analyzed the association between the rs1465040 snp and analgesic requirements,including opioid requirements,after open abdominal surgery. the association between the rs1465040 snp and postoperative analgesic requirements was confirmed in the open abdominal surgery group (p = 0.036),suggesting that the trpc3 snp may contribute to predicting postoperative analgesic requirements. © 2015 japanese pharmacological society. production and hosting by elsevier b.v. all rights reserved.
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کلیدواژه
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Analgesics; Polymorphism; TRPC3
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آدرس
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addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506,japan,department of dental anesthesiology,tokyo dental college,2-9-18 misaki-cho,chiyoda-ku,tokyo,101-0061, Japan, addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506, Japan, addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506, Japan, addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506, Japan, addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506,japan,department of dental anesthesiology,tokyo dental college,2-9-18 misaki-cho,chiyoda-ku,tokyo,101-0061, Japan, department of dental anesthesiology,tokyo dental college,2-9-18 misaki-cho,chiyoda-ku,tokyo,101-0061, Japan, department of dental anesthesiology,tokyo dental college,2-9-18 misaki-cho,chiyoda-ku,tokyo,101-0061, Japan, department of surgery,toho university,sakura medical center,564-1 shimoshizu,sakura,chiba,285-8741, Japan, department of surgery,toho university,sakura medical center,564-1 shimoshizu,sakura,chiba,285-8741, Japan, department of anesthesiology,toho university,sakura medical center,564-1 shimoshizu,sakura,chiba,285-8741, Japan, department of anesthesiology,toho university,sakura medical center,564-1 shimoshizu,sakura,chiba,285-8741, Japan, department of anesthesiology,juntendo university,3-1-3 hongou,bunkyo-ku,tokyo,113-8431, Japan, department of dental anesthesiology,tokyo dental college,2-9-18 misaki-cho,chiyoda-ku,tokyo,101-0061, Japan, addictive substance project,tokyo metropolitan institute of medical science,2-1-6 kamikitazawa,setagaya-ku,tokyo,156-8506, Japan
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Authors
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