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Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice
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نویسنده
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khan m.r.i. ,islam m.t. ,yazawa t. ,hayashi h. ,suzuki y. ,uwada j. ,anisuzzaman a.s.m. ,taniguchi t.
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منبع
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journal of pharmacological sciences - 2015 - دوره : 127 - شماره : 1 - صفحه:150 -153
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چکیده
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Regulation of intestinal secretion is important for body fluid homeostasis. we investigated the role of three map kinases (mapks) as negative regulators in muscarinic cholinoceptor (machr)-mediated intestinal secretion in mice. electrophysiological analyses revealed that machr stimulation enhanced intestinal chloride secretion,which was further augmented by the inhibition of jnk but not by that of erk or p38 with specific inhibitors sp600125,u0126 or sb203580,respectively. immunoblot analyses in colonic mucosa showed that machr stimulation increased mapks phosphorylation that was suppressed by the specific inhibitor for each mapk. this suggests that jnk is a major negative regulator in machr-induced intestinal secretion. © 2014 japanese pharmacological society.
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کلیدواژه
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Intestinal secretion; mAChR; MAP kinase
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آدرس
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division of cellular signal transduction,department of biochemistry,asahikawa medical university,asahikawa,japan,department of pharmacy,university of rajshahi,rajshahi, Bangladesh, division of cellular signal transduction,department of biochemistry,asahikawa medical university,asahikawa, Japan, division of cellular signal transduction,department of biochemistry,asahikawa medical university,asahikawa, Japan, laboratory of physiology,school of food and nutritional sciences,university of shizuoka,shizuoka, Japan, laboratory of physiology,school of food and nutritional sciences,university of shizuoka,shizuoka,japan,division of health and nutrition,sendai shirayuri women's college,sendai, Japan, division of cellular signal transduction,department of biochemistry,asahikawa medical university,asahikawa,japan,laboratory of molecular pharmacology,biosignal research center,kobe university,kobe, Japan, department of pharmacy,university of rajshahi,rajshahi, Bangladesh, division of cellular signal transduction,department of biochemistry,asahikawa medical university,asahikawa, Japan
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Authors
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