|
|
|
|
Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation
|
|
|
|
|
|
|
|
نویسنده
|
kim h.-j. ,park d.j. ,kim j.h. ,jeong e.y. ,jung m.h. ,kim t.-h. ,yang j.i. ,lee g.-w. ,chung h.j. ,chang s.-h.
|
|
منبع
|
journal of pharmacological sciences - 2015 - دوره : 127 - شماره : 1 - صفحه:117 -126
|
|
چکیده
|
Cisplatin is a chemotherapeutic drug but induces acute kidney injury (aki). cisplatin-induced aki depends on several signaling pathways leading to apoptosis in tubular epithelial cells. glutamine is a substrate for the synthesis of glutathione,the most abundant intracellular thiol and antioxidant,and plays an important role in protecting cells from apoptosis induced by different stimuli. in the present study,we investigated the protective effect of glutamine on cisplatin-induced aki. rats were divided into control,glutamine,cisplatin,and cisplatin plus glutamine groups. glutamine ameliorated renal dysfunction,tissue injury,and cisplatin-induced apoptosis. cisplatin increased cell death,caspase-3 cleavage,activation of mapks and p53,oxidative stress,and mrna expression of tnf-α and tnfr1 in hk-2 cells. glutamine treatment reduced cisplatin-induced these changes in hk-2 cells. notably,glutamine reduced the cisplatin-induced expression of organic cation transporter 2 (oct2) and cisplatin accumulation. our results suggest that the protective effect of glutamine on cisplatin is specific for proximal tubular cells and the initial effects may be related to attenuation of cisplatin uptake. thus,glutamine administration might represent a new strategy for the treatment of cisplatin-induced aki. © 2014 japanese pharmacological society.
|
|
کلیدواژه
|
Acute kidney injury; Cisplatin; Cisplatin uptake; Glutamine; Nephrotoxicity
|
|
آدرس
|
division of nephrology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam,south korea,institute of health sciences,gyeongsang national university,jinju,gyeongnam, South Korea, division of nephrology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam,south korea,institute of health sciences,gyeongsang national university,jinju,gyeongnam, South Korea, institute of health sciences,gyeongsang national university,jinju,gyeongnam,south korea,biomedical research institute,gyeongsang national university hospital,jinju,gyeongnam, South Korea, division of nephrology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam, South Korea, biomedical research institute,gyeongsang national university hospital,jinju,gyeongnam, South Korea, biomedical research institute,gyeongsang national university hospital,jinju,gyeongnam, South Korea, division of nephrology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam, South Korea, institute of health sciences,gyeongsang national university,jinju,gyeongnam,south korea,division of hematology-oncology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam, South Korea, college of pharmacy,research institute of pharmaceutical sciences,gyeongsang national university,jinju,gyeongnam, South Korea, division of nephrology,department of internal medicine school of medicine,gyeongsang national university,jinju,gyeongnam,south korea,institute of health sciences,gyeongsang national university,jinju,gyeongnam, South Korea
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|