>
Fa   |   Ar   |   En
   Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor  
   
نویسنده higuchi h. ,yamamoto s. ,ushio s. ,kawashiri t. ,egashira n.
منبع journal of pharmacological sciences - 2015 - دوره : 129 - شماره : 3 - صفحه:196 -199
چکیده    In the present study,we investigated the effect of a kampo medicine goshajinkigan (gjg) on the bortezomib-induced mechanical allodynia in von frey test in rats. the single administration of tramadol (10 mg/kg),gjg (1.0 g/kg) and its component processed aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. these effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body),kappa opioid receptor antagonist. these findings suggest that kappa opioid receptor is involved in the effect of gjg on the bortezomib-induced mechanical allodynia. © 2015 the authors.
کلیدواژه Bortezomib; Goshajinkigan; Peripheral neuropathy
آدرس department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved