Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

In the present study,we investigated the effect of a kampo medicine goshajinkigan (gjg) on the bortezomib-induced mechanical allodynia in von frey test in rats. the single administration of tramadol (10 mg/kg),gjg (1.0 g/kg) and its component processed aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. these effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body),kappa opioid receptor antagonist. these findings suggest that kappa opioid receptor is involved in the effect of gjg on the bortezomib-induced mechanical allodynia. © 2015 the authors.