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Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor
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نویسنده
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higuchi h. ,yamamoto s. ,ushio s. ,kawashiri t. ,egashira n.
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منبع
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journal of pharmacological sciences - 2015 - دوره : 129 - شماره : 3 - صفحه:196 -199
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چکیده
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In the present study,we investigated the effect of a kampo medicine goshajinkigan (gjg) on the bortezomib-induced mechanical allodynia in von frey test in rats. the single administration of tramadol (10 mg/kg),gjg (1.0 g/kg) and its component processed aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. these effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body),kappa opioid receptor antagonist. these findings suggest that kappa opioid receptor is involved in the effect of gjg on the bortezomib-induced mechanical allodynia. © 2015 the authors.
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کلیدواژه
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Bortezomib; Goshajinkigan; Peripheral neuropathy
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آدرس
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department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan
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Authors
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