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Selective sensitization of C-fiber nociceptors by hydrogen sulfide
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نویسنده
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aoki y. ,tsubota m. ,nishimoto y. ,maeda y. ,sekiguchi f. ,kawabata a.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 130 - شماره : 1 - صفحه:38 -41
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چکیده
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We examined the effects of intraplantar (i.pl.) administration of nahs,an h2s donor,known to cause t-type ca2+ channel (t-channel)-dependent mechanical hyperalgesia,on responsiveness to electric stimulation with 5,250 and 2000 hz sine waves (sw) that selectively excites c,aδ and aβ fibers,respectively. nahs,given i.pl.,caused behavioral hypersensitivity to sw stimulation at 5 hz,but not 250 or 2000 hz,in rats. nahs also enhanced phosphorylation of spinal erk following 5 hz sw stimulation. three distinct t-channel blockers abolished the nahs-induced behavioral hypersensitivity to 5 hz sw stimulation. thus,h2s selectively sensitizes c-fiber nociceptors via t-channels. © 2016 japanese pharmacological society.
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کلیدواژه
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C-fiber nociceptor; Hydrogen sulfide; T-type calcium channel
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آدرس
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laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan, laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan, laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan, laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan, laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan, laboratory of pharmacology and pathophysiology,faculty of pharmacy,kindai university,3-4-1 kowakae,higashi-osaka,577-8502, Japan
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Authors
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