|
|
|
|
Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition
|
|
|
|
|
|
|
|
نویسنده
|
imai t. ,kosuge y. ,saito h. ,uchiyama t. ,wada t. ,shimba s. ,ishige k. ,miyairi s. ,makishima m. ,ito y.
|
|
منبع
|
journal of pharmacological sciences - 2016 - دوره : 130 - شماره : 3 - صفحه:185 -188
|
|
چکیده
|
S-allyl-l-cysteine (sac) is known to have neuroprotective properties. we synthesized various sac derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (hpns). among the compounds tested,s-propyl-l-cysteine (spc) exhibited the strongest neuroprotective activity in hpns,followed by s-ethyl-l-cysteine (sec) and s-methyl-l-cysteine (smc). unlike sac and smc,spc and sec did not have inhibitory activity on μ-calpain,suggesting that the mechanism underlying the protective activity of spc and sec differs from that of sac. © 2016 japanese pharmacological society.
|
|
کلیدواژه
|
Endoplasmic reticulum stress; Hippocampal neuron; S-allyl-l-cysteine derivatives
|
|
آدرس
|
laboratory of pharmacology,school of pharmacy,nihon university,7-7-1 narashinodai,funabashi-shi,chiba,274-8555, Japan, laboratory of pharmacology,school of pharmacy,nihon university,7-7-1 narashinodai,funabashi-shi,chiba,274-8555, Japan, laboratory of bio-organic chemistry,school of pharmacy,nihon university,7-7-1,narashinodai,funabashi,chiba,274-8555, Japan, laboratory of bio-organic chemistry,school of pharmacy,nihon university,7-7-1,narashinodai,funabashi,chiba,274-8555, Japan, laboratory of health science,school of pharmacy,nihon university,funabashi,chiba, Japan, laboratory of health science,school of pharmacy,nihon university,funabashi,chiba, Japan, laboratory of pharmacology,school of pharmacy,nihon university,7-7-1 narashinodai,funabashi-shi,chiba,274-8555, Japan, laboratory of bio-organic chemistry,school of pharmacy,nihon university,7-7-1,narashinodai,funabashi,chiba,274-8555, Japan, division of biochemistry,department of biomedical sciences,school of medicine,nihon university,30-1 oyaguchi-kamicho,itabashi-ku,tokyo 173-8610, Japan, laboratory of pharmacology,school of pharmacy,nihon university,7-7-1 narashinodai,funabashi-shi,chiba,274-8555, Japan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|