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Unique immunomodulatory effect of paeoniflorin on type i and II macrophages activities
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نویسنده
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zhai t. ,sun y. ,li h. ,zhang j. ,huo r. ,li h. ,shen b. ,li n.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 130 - شماره : 3 - صفحه:143 -150
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چکیده
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It has been widely accepted that macrophages are divided into m1 pro-inflammatory macrophages and m2 anti-inflammatory macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. as the main substance of total glucosides of peony,paeoniflorin (pf),has been widely used to treat autoimmune and autoinflammatory diseases for years. mechanistically,pf has been found to alter activities of many immune cells,which could further reduce inflammation and tissue damage. however,whether and how pf affects macrophages activities in vitro remains unknown. in current study,using m1 and m2 cells generated from mouse bone marrow precursors,we explored the role of pf in regulating m1/m2 cells activity in vitro. the results showed that pf inhibited lps-induced m1 activity by reducing inos expression and no production via decreasing lps/nf-κb signaling pathway; whereas,pf enhanced il-4-provoked m2 function by up-regulating arg-1 production and activity via increasing il-4/stat6 signaling pathway. our new finding indicates that pf can suppress m1 cells activity and enhance m2 cells function simultaneously,which could help to ameliorate autoimmune and autoinflammatory diseases in clinical treatment. © 2016 japanese pharmacological society.
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کلیدواژه
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Autoimmune and autoinflammatory diseases; M1 macrophage; M2 macrophage; Paeoniflorin
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آدرس
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shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025,china,department of rheumatology,ruijin hospital,shanghai jiao tong university,school of medicine, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025,china,maternity and child health hospital,changning,shanghai, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China, shanghai institute of immunology,department of immunology and microbiology,shanghai jiao tong university,school of medicine,shanghai,200025, China
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Authors
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