Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay

We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). oseltamivir in doses of 3-30 mg/kg,i.v. did not induce torsade de pointes in the canine model,whereas that in concentrations of 30-300 μm decreased maximum rate of phase 0 depolarization,shortened action potential duration at 30%,60% and 90% repolarization levels,but prolonged difference in action-potential duration between 30% and 90% repolarization levels in a concentration-related manner. these results indicate that oseltamivir will not induce torsade de pointes clinically,since it inhibits both inward and outward currents. © 2016 the authors.