5-HT1A receptor agonists,xaliproden and tandospirone,inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice

Oxaliplatin causes peripheral neuropathy as a major dose-limiting side effect,and the control of this neuropathy is difficult. this study was designed to investigate whether prophylactic repetitive administration of 5-ht1a receptor agonists inhibits oxaliplatin-induced mechanical allodynia in mice. repetitive administration of 5-ht1a receptor agonists (xaliproden and tandospirone) inhibited mechanical allodynia induced by a single intraperitoneal injection of oxaliplatin. these agonists also inhibited oxaliplatin-induced mast cell migration,which is involved in the induction of mechanical allodynia. these results suggest that the prophylactic repetitive administration of 5-ht1a receptor agonists attenuates oxaliplatin-induced mechanical allodynia by inhibiting the cutaneous mast cell migration. © 2016 the authors