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Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
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نویسنده
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egashira n. ,iba h. ,kuwano h. ,kawanaka r. ,nagao m. ,moriyama h. ,watanabe t. ,kubota k. ,katsurabayashi s. ,iwasaki k.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 131 - شماره : 4 - صفحه:279 -283
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چکیده
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In the present study,we investigated the effect of kamishoyosan (kss) on conditioned fear-induced freezing in ovariectomized (ovx) rats. socially isolated ovx rats showed the longest freezing time among the following four groups: group-housed sham-operated (sham),isolated sham,group-housed ovx,and isolated ovx rats. repeated oral administration of kss (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated ovx rats. the reduction of freezing by kss was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). these findings suggest that the gabaa-benzodiazepine receptor complex is involved in the anxiolytic effect of kss in socially isolated ovx rats. © 2016 the authors
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کلیدواژه
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Conditioned fear stress; Kamishoyosan; Ovariectomized rats
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آدرس
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department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180,japan,department of pharmacy,kyushu university hospital,fukuoka,812-8582, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180,japan,a.i.g. collaborative research institute for aging and brain sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180, Japan, department of neuropharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka,814-0180,japan,a.i.g. collaborative research institute for aging and brain sciences,fukuoka university,fukuoka,814-0180, Japan
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Authors
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