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Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
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نویسنده
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hosoi t. ,kakimoto m. ,tanaka k. ,nomura j. ,ozawa k.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 131 - شماره : 4 - صفحه:292 -295
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چکیده
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A pharmacological approach to ameliorate alzheimer's disease (ad) has not yet been established. in the present study,we investigated the pharmacological characteristics of the recently identified memory-enhancing compound,isrib for the amelioration of ad. isrib potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nm,but did not inhibit amyloid β production in the hek293t cell line expressing the amyloid precursor protein (app). these results suggest that isrib possesses the unique pharmacological property of attenuating amyloid β-induced neuronal cell death without affecting amyloid β production. © 2016 the authors
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کلیدواژه
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Alzheimer's disease; Amyloid β; ISRIB
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آدرس
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department of pharmacotherapy,graduate school of biomedical and health sciences,hiroshima university,1-2-3 kasumi,minami-ku,hiroshima,734-8553, Japan, department of pharmacotherapy,graduate school of biomedical and health sciences,hiroshima university,1-2-3 kasumi,minami-ku,hiroshima,734-8553, Japan, department of pharmacotherapy,graduate school of biomedical and health sciences,hiroshima university,1-2-3 kasumi,minami-ku,hiroshima,734-8553, Japan, riken brain science institute,2-1 hirosawa,wako,saitama,351-0198, Japan, department of pharmacotherapy,graduate school of biomedical and health sciences,hiroshima university,1-2-3 kasumi,minami-ku,hiroshima,734-8553, Japan
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Authors
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