Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages

Prothymosin alpha (protα) suppresses stress-induced necrosis of cultured cortical neurons. as neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by protα,we further examined whether protα,in addition to neuroprotective effects,has other anti-ischemic activities. when recombinant mouse protα (rmprotα) at 0.3 mg/kg was intravenously (i.v.) given 2 h after the start of tmcao,all mice survived for more than 14 days. in evaluation of cd31- and tomato lectin-labeling as well as igg and evans blue leakage,rmprotα treatment (0.1 mg/kg) largely blocked ischemia-induced vascular damages. therefore,rmprotα has novel beneficial effects against ischemia-induced brain damage through vascular mechanisms. © 2016 the authors