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High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats
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نویسنده
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tran h.-q. ,chung y.h. ,shin e.-j. ,kim w.k. ,lee j.-c. ,jeong j.h. ,wie m.b. ,jang c.-g. ,yamada k. ,nabeshima t. ,kim h.-c.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 132 - شماره : 2 - صفحه:166 -170
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چکیده
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Dextromethorphan (dm) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. we administered dm (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by dm,because intraperitoneal route is sensitive for the behavioral responses. treatment with dm resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. mk-801 [(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated dm-induced cytosolic oxidative burdens. however,neither mk-801 nor naloxone affected dm-induced mitochondrial dysfunction and formation of myelinoid bodies,indicating that the neurotoxic mechanism needs to be further elucidated. therefore,the spectrum of toxicological effects associated with dm need to be reassessed. © 2016 the authors
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کلیدواژه
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Administration route; High-dose dextromethorphan; Myelinoid bodies with mitochondrial dysfunction
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آدرس
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neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon,24341, South Korea, department of anatomy,college of medicine,chung-ang university,seoul,06974, South Korea, neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon,24341, South Korea, department of neuroscience,college of medicine,korea university,seoul,02841, South Korea, department of neurobiology,school of medicine,kangwon national university,chunchon,24341, South Korea, department of pharmacology,college of medicine,chung-ang university,seoul,06974, South Korea, school of veterinary medicine,kangwon national university,chunchon,24341, South Korea, department of pharmacology,school of pharmacy,sungkyunkwan university,suwon,16419, South Korea, department of neuropsychopharmacology and hospital pharmacy,nagoya university graduate school of medicine,nagoya,466-8560, Japan, advanced diagnostic system research laboratory,fujita health university graduate school of health scienceaichi 470-1192, Japan, neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon,24341, South Korea
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Authors
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