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Defective splicing of the background K+ channel K2P5.1 by the pre-mRNA splicing inhibitor,pladienolide B in lectin-activated mouse splenic CD4+ T cells
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نویسنده
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tagishi k. ,shimizu a. ,endo k. ,kito h. ,niwa s. ,fujii m. ,ohya s.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 132 - شماره : 3 - صفحه:205 -209
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چکیده
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The two-pore domain k+ channel k2p5.1 has been implicated in the pathogenesis of autoimmune diseases. we investigated the changes in k2p5.1 activity caused by a defect in normal pre-mrna splicing in concanavalin a-activated mouse splenic cd4+ t cells. the pre-mrna splicing inhibitor,pladienolide b (1 μm) markedly decreased full-length k2p5.1 transcription in activated cd4+ t cells,resulting in the disappearance of k2p5.1 activity and an imbalance in th17 and treg cytokines. these results suggest that the defect in k2p5.1 splicing by the pre-mrna splicing inhibitor regulates pro- and/or anti-inflammatory cytokine production in k2p5.1-associated autoimmune diseases. © 2016 the authors
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کلیدواژه
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K2P5.1; K+ channel; Pre-mRNA splicing inhibitor
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آدرس
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department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan, department of pharmacology,division of pathological sciences,kyoto pharmaceutical university,kyoto,607-8414, Japan
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Authors
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