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LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
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نویسنده
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hayashi k. ,jutabha p. ,maeda s. ,supak y. ,ouchi m. ,endou h. ,fujita t. ,chida m. ,anzai n.
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منبع
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journal of pharmacological sciences - 2016 - دوره : 132 - شماره : 3 - صفحه:201 -204
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چکیده
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L-type amino acid transporter 1 (lat1,slc7a5) incorporates essential amino acids into cells. recent studies have shown that lat1 is a predominant transporter in various human cancers. however,the function of lat1 in thymic carcinoma remains unknown. here we demonstrate that lat1 is a critical transporter for human thymic carcinoma cells. lat1 was strongly expressed in human thymic carcinoma tissues. lat1-specific inhibitor significantly suppressed leucine uptake and growth of ty82 human thymic carcinoma cell lines,suggesting that thymic carcinoma takes advantage of lat1 as a quality transporter and that lat1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma. © 2016 the authors
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کلیدواژه
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Anticancer drug; Thymic carcinoma; Transporter
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آدرس
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department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of general thoracic surgery,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, j-pharma co.,ltd.,yokohama,kanagawa 230-0046, Japan, department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of general thoracic surgery,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university school of medicine,shimotsuga,tochigi 321-0293,japan,department of pharmacology,chiba university graduate school of medicine,chuo,chiba 260-8670, Japan
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Authors
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