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   Effects of new antiarrhythmic agent SS-68 on excitation conduction,electrical activity in Purkinje fibers and pulmonary veins: Assessment of safety and side effects risk  
   
نویسنده bogus s.k. ,kuzmin v.s. ,abramochkin d.v. ,suzdalev k.f. ,galenko-yaroshevsky p.a.
منبع journal of pharmacological sciences - 2017 - دوره : 133 - شماره : 3 - صفحه:122 -129
چکیده    The compound ss-68 has been selected among numerous new derivatives of indole and demonstrated antiarrhythmic effects in animal models. the present study concerns several aspects of ss-68 safety and efficacy as a potential antiarrhythmic drug. the first estimation of atrioventricular conduction in mammalian heart under ss-68 has been carried out; effects of ss-68 in purkinje fibers and myocardium of pulmonary veins have been investigated. the drug weakly affects cardiac atrioventricular conduction: only high concentrations of ss-68 (≥10 μmol/l) significantly decrease this parameter. also,the drug weakly affects purkinje fibers automaticity,but effectively alters action potential waveform in purkinje fibers in a concentration-dependent manner. ss-68 (0.1–100 μmol/l) failed to induce any early or delayed afterdepolarizations in purkinje fibers both in basal conditions and under provocation of proarrhythmic activity by norepinephrine (ne). moreover,10 μmol/l ss-68 suppressed ne-induced extra-beats and rapid firing in purkinje fibers. in pulmonary veins only high concentrations of ss-68 significantly increased action potential duration,while lower concentrations (0.1–1 μmol/l) were ineffective. also,0.1–100 μmol/l ss-68 was unable to elicit arrhythmogenic alternations of action potential waveform in pulmonary veins. in conclusion,ss-68 has no proarrhythmic effects,such as afterdepolarizations or abnormal automaticity in used experimental models. © 2017 the authors
کلیدواژه Action potential; Antiarrhythmic drug; Arrhythmia; Conduction; Pulmonary veins
آدرس kuban’ state medical university,sedina,4,krasnodar, Russian Federation, lomonosov moscow state university,leninskie gory,1,moscow,russian federation,pirogov russian national research medical university,ostrovityanova,1,moscow, Russian Federation, lomonosov moscow state university,leninskie gory,1,moscow,russian federation,pirogov russian national research medical university,ostrovityanova,1,moscow, Russian Federation, chemical department of southern federal university,zorge,7,rostov-on-don, Russian Federation, kuban’ state medical university,sedina,4,krasnodar, Russian Federation
 
     
   
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