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The iron chelating agent,deferoxamine detoxifies Fe(Salen)-induced cytotoxicity
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نویسنده
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umemura m. ,kim j.-h. ,aoyama h. ,hoshino y. ,fukumura h. ,nakakaji r. ,sato i. ,ohtake m. ,akimoto t. ,narikawa m. ,tanaka r. ,fujita t. ,yokoyama u. ,taguri m. ,okumura s. ,sato m. ,eguchi h. ,ishikawa y.
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منبع
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journal of pharmacological sciences - 2017 - دوره : 134 - شماره : 4 - صفحه:203 -210
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چکیده
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Iron-salen,i.e.,μ-oxo-n,n′-bis(salicylidene)ethylenediamine iron (fe(salen)) was a recently identified as a new anti-cancer compound with intrinsic magnetic properties. chelation therapy has been widely used in management of metallic poisoning,because an administration of agents that bind metals can prevent potential lethal effects of particular metal. in this study,we confirmed the therapeutic effect of deferoxamine mesylate (dfo) chelation against fe(salen) as part of the chelator antidote efficacy. dfo administration resulted in reduced cytotoxicity and ros generation by fe(salen) in cancer cells. dfo (25 mg/kg) reduced the onset of fe(salen) (25 mg/kg)-induced acute liver and renal dysfunction. dfo (300 mg/kg) improves survival rate after systematic injection of a fatal dose of fe(salen) (200 mg/kg) in mice. dfo enables the use of higher fe(salen) doses to treat progressive states of cancer,and it also appears to decrease the acute side effects of fe(salen). this makes dfo a potential antidote candidate for fe(salen)-based cancer treatments,and this novel strategy could be widely used in minimally-invasive clinical settings. © 2017 the authors
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کلیدواژه
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Anti-cancer; Antidote; Chelate; Deferoxamine (DFO); Fe(Salen)
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آدرس
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cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, department of environment and natural sciences,graduate school of environment and information sciences,yokohama national university,79-7,tokiwada,hodogaya,yokohama,240-8501, Japan, fukumura orthopedic clinic,1869-1 shimokurata,hanatachi,yokohama,244-0815, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004,japan,department of oral and maxillofacial surgery,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, sato oral and maxillofacial surgery clinic,1-6-27 2f,zushi,zushi,249-0006, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004,japan,department of neurosurgery,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004,japan,department of neurosurgery,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, department of biostatistics,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan, tsurumi university school of dental medicine,2-1-3,tsurumi,yokohama,230-8501, Japan, department of physiology,aichi medical university,1-1,yazakokarimata,nagakute,aichi,480-1103, Japan, advanced applied science department,research laboratory,ihi corporation,shinnakaharamachi,isogo,yokohama,235-8501, Japan, cardiovascular research institute,yokohama city university,graduate school of medicine,3-9 fukuura,kanazawa-ku,yokohama,236-0004, Japan
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Authors
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