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   The effects of dipeptidyl peptidase-4 on cardiac fibrosis in pressure overload-induced heart failure  
   
نویسنده hirose m. ,takano h. ,hasegawa h. ,tadokoro h. ,hashimoto n. ,takemura g. ,kobayashi y.
منبع journal of pharmacological sciences - 2017 - دوره : 135 - شماره : 4 - صفحه:164 -173
چکیده    Dipeptidyl peptidase-4 (dpp-4) inhibitors are hypoglycemic agents. dpp-4 inhibitor has cardioprotective effects after transverse aortic constriction (tac),but role of dpp-4 on cardiac fibrosis after tac is not well known. our aim was to determine the effects of dpp-4 on cardiac fibrosis in murine tac model. wild-type mice and dpp-4 knockout mice were subjected to tac. wild-type mice were then treated with vehicle or dpp-4 inhibitor. dpp-4 activities in serum and heart tissue were significantly increased at 2 weeks after tac,but they were significantly decreased by dpp-4 inhibitor treatment. the inhibition of dpp-4 did not affect left ventricular hypertrophy,but improved cardiac function and decreased myocardial and perivascular fibrosis after tac. the inhibition of dpp-4 decreased the collagen type iii/i ratio in myocardium. these results suggest that dpp-4 inhibition ameliorates the progression of heart failure after tac by changing the quality and quantity of cardiac fibrosis. © 2017 the authors
کلیدواژه cardiac fibrosis; Cardiac hypertrophy; Collagen; DPP-4; Heart failure
آدرس department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of molecular cardiovascular pharmacology,chiba university graduate school of pharmaceutical sciences,chiba,260-8675, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of molecular cardiovascular pharmacology,chiba university graduate school of pharmaceutical sciences,chiba,260-8675, Japan, department of internal medicine,asahi university school of medicine,mizuho,501-0296, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan
 
     
   
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