|
|
The effects of dipeptidyl peptidase-4 on cardiac fibrosis in pressure overload-induced heart failure
|
|
|
|
|
نویسنده
|
hirose m. ,takano h. ,hasegawa h. ,tadokoro h. ,hashimoto n. ,takemura g. ,kobayashi y.
|
منبع
|
journal of pharmacological sciences - 2017 - دوره : 135 - شماره : 4 - صفحه:164 -173
|
چکیده
|
Dipeptidyl peptidase-4 (dpp-4) inhibitors are hypoglycemic agents. dpp-4 inhibitor has cardioprotective effects after transverse aortic constriction (tac),but role of dpp-4 on cardiac fibrosis after tac is not well known. our aim was to determine the effects of dpp-4 on cardiac fibrosis in murine tac model. wild-type mice and dpp-4 knockout mice were subjected to tac. wild-type mice were then treated with vehicle or dpp-4 inhibitor. dpp-4 activities in serum and heart tissue were significantly increased at 2 weeks after tac,but they were significantly decreased by dpp-4 inhibitor treatment. the inhibition of dpp-4 did not affect left ventricular hypertrophy,but improved cardiac function and decreased myocardial and perivascular fibrosis after tac. the inhibition of dpp-4 decreased the collagen type iii/i ratio in myocardium. these results suggest that dpp-4 inhibition ameliorates the progression of heart failure after tac by changing the quality and quantity of cardiac fibrosis. © 2017 the authors
|
کلیدواژه
|
cardiac fibrosis; Cardiac hypertrophy; Collagen; DPP-4; Heart failure
|
آدرس
|
department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of molecular cardiovascular pharmacology,chiba university graduate school of pharmaceutical sciences,chiba,260-8675, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan, department of molecular cardiovascular pharmacology,chiba university graduate school of pharmaceutical sciences,chiba,260-8675, Japan, department of internal medicine,asahi university school of medicine,mizuho,501-0296, Japan, department of cardiovascular medicine,chiba university graduate school of medicine,chiba,260-8670, Japan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|