Prostanoid DP receptor (PTGDR) variants in mothers with post-coital associated preterm births: preliminary observations

Objective:to describe prostanoid dp receptor (ptgdr) variants in women with preterm births who admitted to coital activity (ca) within 24 h of labor.study design:to achieve >80% statistical power, a pilot case-control study compared 24 premature births from mothers with ca (group 1), 30 mothers of premature infants who did not have ca (group 2 non-coital activity) and 95 non-coital activity mothers with term births (group 3 controls). four functional ptdgr single nucleotide polymorphisms (snps) were evaluated: t-549c, c-441/t, t-197c and g+1044a. phase 2.0.2 and sas 9.2 were used for analysis.result:all snps were in hardy–weinberg equilibrium in controls. the c-441/t genotype frequency was significantly increased among group 1 women relative to group 2 and 3 women (odds ratio (or): 30.1, 95% confidence interval (ci) 6.9–191 and 25.7 95%ci 25.7-not computible, respectively). of the possible haplotypes among the groups, the tctg haplotype (t-549c, c-441/t, t-197c and g+1044a) was significantly more frequent in group 1 women compared with the control groups (or 53.4, 95%ci 10.3–554.8).conclusions:a differential genomic pattern of ptgdr polymorphisms was identified in a sub-set of mothers which was associated with an increased risk of post-coital preterm birth.