Case report: a black and white twin

Albinism is an autosomal recessive disorder that is caused by a defective synthesis of melanin, resulting in a generalized reduction of pigmentation in the skin, hair and eyes, and leading to an increased risk of skin cancer and vision problems. we report a case of a 22-year-old primigravida of negroid origin who delivered dichorial diamniotic twins: two daughters were born with a totally different appearance. the first child had a light brown skin, black curly hair and brown eyes, whereas the second had a striking white skin, red-blond curly hair and blue eyes. oculocutaneous albinism (oca) and heteropaternal superfecundation were considered in the differential diagnosis. genetic testing confirmed the diagnosis of oca type 2 in the second child. the diagnosis of albinism has clinical implications and must be considered when a black and white twin is born.