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Extremely high phenylalanine levels in a newborn on parenteral nutrition: phenylketonuria in the neonatal intensive care unit
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نویسنده
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Lin H J ,Kwong A M ,Carter J M ,Ferreira B F ,Austin M F ,Devarajan K ,Coleman R J ,Feuchtbaum L B ,Lorey F ,Jonas A J
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منبع
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journal of perinatology - 2011 - دوره : 31 - شماره : 7 - صفحه:507 -510
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چکیده
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A 1890-g newborn on total parenteral nutrition (tpn) had phenylalanine levels reaching 4164 μm indicating phenylketonuria (pku). review of 64 pku cases from the california newborn screening program disclosed another newborn diagnosed while on tpn. phenylalanine levels rose five times faster with tpn, as estimated from rates in these infants. thus, tpn use is associated with very high phenylalanine levels in newborns with pku. when starting tpn soon after birth (for example, on day 1), early detection of pku—by newborn screening 12 to 24 h after infusions are begun—should be helpful in limiting exposures to toxic levels of phenylalanine.
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آدرس
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Harbor-UCLA Medical Center, Division of Medical Genetics, Department of Pediatrics, USA, Harbor-UCLA Medical Center, Division of Medical Genetics, Department of Pediatrics, USA, California Department of Public Health, Genetic Disease Screening Program, USA. Public Health Foundation Enterprises, USA, Harbor-UCLA Medical Center, Division of Medical Genetics, Department of Pediatrics, USA, Harbor-UCLA Medical Center, Division of Medical Genetics, Department of Pediatrics, USA, St Francis Medical Center, Department of Neonatology, USA, University of California—Irvine, Department of Pediatrics, USA, California Department of Public Health, Genetic Disease Screening Program, USA, California Department of Public Health, Genetic Disease Screening Program, USA, Harbor-UCLA Medical Center, Division of Medical Genetics, Department of Pediatrics, USA
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Authors
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