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Pilot trial of late booster doses of surfactant for ventilated premature infants
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نویسنده
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Merrill J D ,Ballard P L ,Courtney S E ,Durand D J ,Hamvas A ,Hibbs A M ,Lu K W ,Ryan R M ,Reynolds A M ,Spence K ,Steinhorn R H ,Truog W E ,Eichenwald E C ,Ballard R A
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منبع
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journal of perinatology - 2011 - دوره : 31 - شماره : 9 - صفحه:599 -606
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چکیده
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Objective:many premature infants at risk for bronchopulmonary dysplasia experience episodes of surfactant dysfunction with reduced surfactant protein b (sp-b). in this study, we investigated the safety and responses to booster doses of surfactant.study design:a total of 87 infants, 500 to 1250 g birth weight, who were ventilated at 7 to 10 days received 2 or 3 doses of infasurf (calfactant, forest pharmaceuticals, st louis, mo, usa) within a 1-week period.result:for 184 doses, occurrence rates of transient bradycardia (13) and plugged endotracheal tube (5) were low, and no other adverse effects were noted. treatment transiently improved the respiratory severity score (fio2 × mean airway pressure), sp-b content (+75%) and surface properties of isolated surfactant. levels of eight proinflammatory cytokines in tracheal aspirate were interrelated and unchanged from baseline after surfactant treatment.conclusion:booster doses of surfactant for premature infants with lung disease are safe and transiently improve respiratory status as well as composition and function of endogenous surfactant.
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آدرس
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Children's Hospital and Research Center Oakland, Department of Pediatrics, USA, University of California San Francisco, Department of Pediatrics, USA, Stony Brook University Medical Center, Department of Pediatrics, USA, Children's Hospital and Research Center Oakland, Department of Pediatrics, USA, Washington University, Department of Pediatrics, USA, Case Western Reserve University, Department of Pediatrics, USA, University of California San Francisco, Department of Pediatrics, USA, Children's Hospital Buffalo, Department of Pediatrics, USA, Children's Hospital Buffalo, Department of Pediatrics, USA, St Louis University School of Medicine, Department of Pediatrics, USA, Northwestern Memorial Hospital and Children's Memorial Hospital, Department of Pediatrics, USA, Children's Mercy Hospitals and Clinics/University of Missouri-Kansas City School of Medicine, Department of Pediatrics, USA, University of Texas Health Science Center Houston, Department of Pediatrics, USA, University of California San Francisco, Department of Pediatrics, USA
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Authors
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