|
|
|
|
Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants
|
|
|
|
|
|
|
|
نویسنده
|
Rubin L P ,Chan G M ,Barrett-Reis B M ,Fulton A B ,Hansen R M ,Ashmeade T L ,Oliver J S ,Mackey A D ,Dimmit R A ,Hartmann E E ,Adamkin D H
|
|
منبع
|
journal of perinatology - 2012 - دوره : 32 - شماره : 6 - صفحه:418 -424
|
|
چکیده
|
Objective:dietary carotenoids (lutein, lycopene and β-carotene) may be important in preventing or ameliorating prematurity complications. little is known about carotenoid status or effects of supplementation.study design:this randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n=203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and β-carotene with human milk (hm)-fed term infants. we assessed safety and health.result:plasma carotenoid levels were higher in the supplemented group at all time points (p<0.0001) and were similar to those of term hm-fed infants. supplemented infants had lower plasma c-reactive protein (p<0.001). plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r=0.361, p=0.05). the supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; p<0.05).conclusion:carotenoid supplementation for preterm infants raises plasma concentrations to those observed in hm-fed term infants. carotenoid supplementation may decrease inflammation. our results point to protective effects of lutein on preterm retina health and maturation.
|
|
|
|
|
آدرس
|
University of South Florida, Department of Pediatrics, USA, University of Utah, Department of Pediatrics, USA, Abbott Nutrition, Abbott Laboratories, Abbott Laboratories, USA, Harvard Medical School, Department of Ophthalmology, USA, Harvard Medical School, Department of Ophthalmology, USA, University of South Florida, Department of Pediatrics, USA, Abbott Nutrition, Abbott Laboratories, Abbott Laboratories, USA, Abbott Nutrition, Abbott Laboratories, Abbott Laboratories, USA, University of Alabama, Department of Pediatrics, USA, University of Alabama, Department of Optometry, USA, University of Louisville, Department of Pediatrics, USA
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|