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Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population
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نویسنده
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Mann P C ,Cooper M E ,Ryckman K K ,Comas B ,Gili J ,Crumley S ,Bream E N A ,Byers H M ,Piester T ,Schaefer A ,Christine P J ,Lawrence A ,Schaa K L ,Kelsey K J P ,Berends S K ,Momany A M ,Gadow E ,Cosentino V ,Castilla E E ,Camelo J López ,Saleme C ,Day L J ,England S K ,Marazita M L ,Dagle J M ,Murray J C
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منبع
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journal of perinatology - 2013 - دوره : 33 - شماره : 5 - صفحه:336 -340
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چکیده
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Objective:to investigate genetic etiologies of preterm birth (ptb) in argentina through evaluation of single-nucleotide polymorphisms (snps) in candidate genes and population genetic admixture.study design:genotyping was performed in 389 families. maternal, paternal and fetal effects were studied separately. mitochondrial dna (mtdna) was sequenced in 50 males and 50 females. y-chromosome anthropological markers were evaluated in 50 males.result:fetal association with ptb was found in the progesterone receptor (pgr, rs1942836; p=0.004). maternal association with ptb was found in small conductance calcium activated potassium channel isoform 3 (kcnn3, rs883319; p=0.01). gestational age associated with ptb in pgr rs1942836 at 32–36 weeks (p=0.0004). mtdna sequencing determined 88 individuals had amerindian consistent haplogroups. two individuals had amerindian y-chromosome consistent haplotypes.conclusion:this study replicates single locus fetal associations with ptb in pgr, maternal association in kcnn3, and demonstrates possible effects for divergent racial admixture on ptb.
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آدرس
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University of Iowa, Department of Pediatrics, USA, University of Pittsburgh, Department of Human Genetics, USA, University of Iowa, Department of Pediatrics, USA, Centro de Educación Médica e Investigaciones Clínicas, Argentina. Instituto Oswaldo Cruz, Brazil, Centro de Educación Médica e Investigaciones Clínicas, Argentina. Instituto Oswaldo Cruz, Brazil, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, Centro de Educación Médica e Investigaciones Clínicas, Argentina, Centro de Educación Médica e Investigaciones Clínicas, Argentina, Centro de Educación Médica e Investigaciones Clínicas, Argentina. Instituto Oswaldo Cruz, Brazil, Centro de Educación Médica e Investigaciones Clínicas, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina. Instituto Multidisciplinario de Biología Celular, Argentina, Instituto de Maternidad y Ginecología Nuestra Señora de las Mercedes, Argentina, University of Iowa, Department of Obstetrics and Gynecology, USA, University of Iowa, Department of Obstetrics and Gynecology, Department of Molecular Physiology and Biophysics, USA, University of Pittsburgh, Department of Human Genetics, USA, University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA
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Authors
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