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Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants
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نویسنده
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Wynn J L ,Li L ,Cotten C M ,Phelps D L ,Shankaran S ,Goldberg R N ,Carlo W A ,Meurs K Van ,Das A ,Vohr B R ,Higgins R D ,Stoll B J ,D'Angio C T
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منبع
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journal of perinatology - 2013 - دوره : 33 - شماره : 8 - صفحه:613 -618
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چکیده
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Objective:sepsis in older children and adults modifies immune system function. we compared serotype-specific antibody responses to heptavalent pneumococcal conjugate vaccine (pcv7) in very low birth weight infants (<1500 g,vlbws) with and without blood stream infection (bsi) during their birth hospitalization.study design:retrospective analysis of prospectively collected data for the neonatal research network study of pcv7 responses among vlbws. infants received pcv7 at 2, 4 and 6 months after birth with blood drawn 4 to 6 weeks after third dose. serotype antibodies were compared between infants with or without a history of bsi. regression models were constructed with bw groups and other confounding factors identified in the primary study.result:in all, 244 infants completed the vaccine series and had serum antibody available; 82 had bsi. after adjustment, bsi was not associated with reduced odds of serum antibody ⩾0.35 μg ml−1.conclusion:bsi was not associated with reduced odds of world health organization-defined protective pcv7 responses in vlbws.
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آدرس
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Vanderbilt University Medical Center, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, USA, Statistics and Epidemiology Unit, USA, Vanderbilt University Medical Center, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, USA. Duke University, Department of Pediatrics, USA, University of Rochester School of Medicine and Dentistry, Department of Pediatrics, USA, Wayne State University, Department of Pediatrics, USA, Duke University, Department of Pediatrics, USA, University of Alabama at Birmingham, Department of Pediatrics, Division of Neonatology, USA, Stanford University School of Medicine and Lucile Packard Children's Hospital, Division of Neonatal and Developmental Medicine, Department of Pediatrics, USA, Statistics and Epidemiology Unit, RTI International, USA, Brown University, Department of Pediatrics, USA, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA, Emory University School of Medicine, Department of Pediatrics, USA, University of Rochester School of Medicine and Dentistry, Department of Pediatrics, USA
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Authors
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