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High oleic/stearic fatty-acid desaturation index in cord plasma from infants of mothers with gestational diabetes
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نویسنده
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Yee J K ,Mao C S ,Ross M G ,Lee W N P ,Desai M ,Toda A ,Kjos S L ,Hicks R A ,Patterson M E
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منبع
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journal of perinatology - 2014 - دوره : 34 - شماره : 5 - صفحه:357 -363
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چکیده
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Objective:enhanced fatty-acid desaturation by stearoyl-coa desaturase enzyme-1 (scd1) is associated with obesity. this study determined desaturation in the cord plasma of newborns of mothers with and without gestational diabetes (gdm).study design:newborns of mothers with gdm (n=21) and without (control, n=22) were recruited. cord plasma fatty-acid desaturation indices (palmitoleic/palmitic, oleic/stearic ratios) were compared, and correlated with anthropometrics and biochemical measures. a subset of very low-density lipoprotein (vldl) desaturation indices were determined to approximate the liver scd1 activity.result:the total oleic/stearic index was higher in gdm, despite adjustment for cord glucose concentrations. among gdm and controls, the oleic/stearic index correlated with cord glucose concentrations (rs=0.36, p=0.02). both palmitoleic/palmitic and oleic/stearic indices correlated with waist circumference (r=0.47, p=0.001; r=0.37, p=0.01). the vldl oleic/stearic index was higher in gdm.conclusion:the elevated total oleic/stearic index suggests increased lipogenesis in gdm newborns. factors in addition to glucose supply may influence fetal scd1 activity.
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آدرس
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Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Division of Endocrinology, Department of Pediatrics, USA, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Division of Endocrinology, Department of Pediatrics, USA, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, USA, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Division of Endocrinology, Department of Pediatrics, USA, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, USA, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, USA, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology, USA, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Division of Endocrinology, Department of Pediatrics, USA, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Division of Endocrinology, Department of Pediatrics, USA
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Authors
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