Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III

Objective:bayley-iii scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used bayley-ii. our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using bayley iii and the predictive value of magnetic resonance imaging (mri) in infants who received systemic hypothermia.study design:we conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from october 2005–november 2011.result:eighty newborns underwent hypothermia (incidence of 1/1000). of the survivors, 89% had bayley-iii performed around 24 months of age. an abnormal outcome using bayley-iii <85 occurred in 50%, while bayley iii <70 occurred in 13%. mri predicted bayley iii<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.conclusion:a bayley-iii 85 cutoff identifies a disability rate of 50%, and mri was predictive of abnormal outcomes. findings can be useful for counseling of families and planning of future studies using bayley iii.