The impact of first trimester fasting glucose level on adverse perinatal outcome

Objectiveto evaluate the impact of first trimester fasting glucose (ftfg) level on perinatal outcome.study designa retrospective cohort study of singleton deliveries. maternal and neonatal outcome were compared between two groups—women with ftfg < 95 mg/dl and ftfg ≥ 95 mg/dl. women with pre-gestational diabetes were excluded.resultsfive thousand and thirty women met inclusion criteria. of whom, 4644 (92.3%) had ftfg < 95 mg/dl and 386 (7.7%) had ftfg ≥ 95 mg/dl. women with ftfg ≥ 95 mg/dl had higher rates of gestational hypertension (2.33 vs. 0.7%) and gestational diabetes (9.07 vs. 2.86%), p < 0.05 for both. moreover, they had higher rates of cesarean delivery and arrest of descent, p < 0.05. composite diabetes outcome was significantly higher among women with ftfg ≥ 95 mg/dl (8 vs. 3%, p = 0.002).after adjusting for potential confounders, composite diabetes outcome (aor = 1.942 95% ci 1.265–2.981, p = 0.002) and gestational hypertension (aor = 2.827 95% ci 1.295–6.175, p = 0.009) remained significantly higher in the ftfg ≥ 95 mg/dl group.conclusionftfg ≥ 95 mg/dl is an independent risk factor for adverse perinatal outcome including gestational hypertension and diabetes-related complications.