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Second trimester serum cortisol and preterm birth: an analysis by timing and subtype
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نویسنده
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Bandoli Gretchen ,Jelliffe-Pawlowski Laura L ,Feuer Sky K ,Liang Liang ,Oltman Scott P ,Paynter Randi ,Ross Kharah M ,Schetter Christine Dunkel ,Ryckman Kelli K ,Chambers Christina D
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منبع
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journal of perinatology - 2018 - دوره : 38 - شماره : 8 - صفحه:973 -981
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چکیده
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Objectivewe hypothesized second trimester serum cortisol would be higher in spontaneous preterm births compared to provider-initiated (previously termed ‘medically indicated’) preterm births.study designwe used a nested case-control design with a sample of 993 women with live births. cortisol was measured from serum samples collected as part of routine prenatal screening. we tested whether mean-adjusted cortisol fold-change differed by gestational age at delivery or preterm birth subtype using multivariable linear regression.resultan inverse association between cortisol and gestational age category (trend p = 0.09) was observed. among deliveries prior to 37 weeks, the mean-adjusted cortisol fold-change values were highest for preterm premature rupture of the membranes (1.10), followed by premature labor (1.03) and provider-initiated preterm birth (1.01), although they did not differ statistically.conclusioncortisol continues to be of interest as a marker of future preterm birth. augmentation with additional biomarkers should be explored.
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آدرس
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University of California San Diego, Department of Pediatrics, USA, University of California San Francisco School of Medicine, Department of Epidemiology & Biostatistics, USA, University of California San Francisco School of Medicine, Department of Obstetrics, USA, Stanford University, Department of Genetics, USA, University of California San Francisco School of Medicine, Department of Epidemiology & Biostatistics, USA, University of California San Francisco School of Medicine, Department of Epidemiology & Biostatistics, USA, University of California Los Angeles, Department of Psychology, USA, University of California Los Angeles, Department of Psychology, USA, University of Iowa, Departments of Epidemiology and Pediatrics, USA, University of California San Diego, Department of Pediatrics, USA
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Authors
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