|
|
Plasma proteome changes in cord blood samples from preterm infants
|
|
|
|
|
نویسنده
|
Suski Maciej ,Bokiniec Renata ,Szwarc-Duma Monika ,Madej Józef ,Bujak-Giżycka Beata ,Borszewska-Kornacka Maria Katarzyna ,Książek Teofila ,Grabowska Agnieszka ,Revhaug Cecilie ,Baumbusch Lars O. ,Saugstad Ola D. ,Pietrzyk Jacek Józef ,Kwinta Przemko
|
منبع
|
journal of perinatology - 2018 - دوره : 38 - شماره : 9 - صفحه:1182 -1189
|
چکیده
|
Objectivein the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants.study designpreterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition.resultpreterm delivery is associated with multiple protein abundance changes in plasma related to a plethora of processes, including inflammation and immunomodulation, coagulation, and complement activation as some key features.conclusionplasma proteome analysis revealed numerous gestation-age-dependent protein abundance differences between term and preterm infants, which highlight key dysregulated pathways and potential new protein treatment targets.
|
|
|
آدرس
|
Jagiellonian University Medical College, Poland, Department of Neonatology and Intensive Care Warsaw Medical University, Poland, Department of Neonatology and Intensive Care Warsaw Medical University, Poland, Jagiellonian University Medical College, Poland, Jagiellonian University Medical College, Poland, Department of Neonatology and Intensive Care Warsaw Medical University, Poland, Jagiellonian University Medical College, Department of Pediatrics, Poland, Jagiellonian University Medical College, Department of Pediatrics, Poland, Oslo University Hospital, Department of Pediatric Research, Norway. University of Oslo, Norway, Oslo University Hospital, Department of Pediatric Research, Norway, Oslo University Hospital, Department of Pediatric Research, Norway. University of Oslo, Norway, Jagiellonian University Medical College, Department of Pediatrics, Poland, Jagiellonian University Medical College, Department of Pediatrics, Poland
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|