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Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia
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نویسنده
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Varner Michael W. ,Mele Lisa ,Casey Brian M. ,Peaceman Alan M. ,Sorokin Yoram ,Reddy Uma M. ,Wapner Ronald J. ,Thorp John M. ,Saade George R. ,Tita Alan T. N. ,Rouse Dwight J. ,Sibai Baha ,Iams Jay D. ,Mercer Brian M. ,Tolosa Jorge ,Caritis Steve N.
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منبع
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journal of perinatology - 2018 - دوره : 38 - شماره : 11 - صفحه:1490 -1495
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چکیده
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Objectiveto assess whether treatment of pregnant women with subclinical hypothyroidism or hypothyroxinemia alters neonatal tsh results.study designa planned secondary analysis of data from two multi-center randomized, double-masked, placebo-controlled thyroxine replacement trials in pregnant women with either subclinical hypothyroidism or hypothyroxinemia. infant heel-stick specimens were obtained before discharge. we compared tsh levels between neonates born to mothers allocated to treatment or placebo within each trial and between neonates in the placebo groups. multiples of means were generated for day-of-life-specific data.resultsneonatal tsh values were available for 573/677 (84.6%) newborns from the subclinical hypothyroidism trial and 461/526 (87.6%) newborns from the hypothyroxinemia trial. neonatal tsh values did not differ in either trial by treatment group or between placebo groups (p > 0.05 for all comparisons).conclusionsneonatal tsh values did not differ with thyroid hormone replacement in pregnancies diagnosed with subclinical hypothyroidism or hypothyroxinemia.
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آدرس
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Department of Obstetrics and Gynecology of the University of Utah Health Sciences Center, USA, George Washington University Biostatistics Center, USA, University of Texas - Southwestern, USA, Northwestern University, USA, Wayne State University, USA, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA, Columbia University, USA, University of North Carolina, USA, University of Texas Medical Branch, USA, University of Alabama at Birmingham, USA, Brown University, USA, University of Texas – Houston, USA, Ohio State University, USA, Case Western Reserve University, USA, Oregon Health Sciences University, USA, University of Pittsburgh, USA
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Authors
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