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Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia
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نویسنده
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Ross Kharah M. ,Baer Rebecca J. ,Ryckman Kelli ,Feuer Sky K. ,Bandoli Gretchen ,Chambers Christina ,Flowers Elena ,Liang Liang ,Oltman Scott ,Schetter Christine Dunkel ,Jelliffe-Pawlowski Laura
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منبع
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journal of perinatology - 2019 - دوره : 39 - شماره : 2 - صفحه:314 -320
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چکیده
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Objectiveinflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. however, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.study designa sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. backwards-stepwise logistic regression models were used to calculate odds ratios.resultshigher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia.conclusionsamong women with preterm births, those who developed preeclampsia differed with respect metabolic markers. these findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.
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آدرس
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University of California Los Angeles, Department of Psychology, USA, University of California San Diego, Department of Pediatrics, USA, University of Iowa, Department of Epidemiology, USA, University of California San Francisco School of Medicine, Department of Obstetrics, USA. University of California San Francisco, USA, University of California San Francisco, USA, University of California San Francisco, USA, University of California School of Nursing, Department of Physiological Nursing, USA, Stanford University School of Medicine, Department of Genetics, USA, University of California San Francisco School of Medicine, Department of Obstetrics, Department of Epidemiology and Biostatistics, USA, University of California Los Angeles, Department of Psychology, USA, University of Iowa, Department of Epidemiology, USA. University of California San Francisco School of Medicine, Department of Epidemiology and Biostatistics, USA
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Authors
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