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Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children
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نویسنده
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Duncan Andrea F. ,Bann Carla M. ,Dempsey Allison G. ,Adams-Chapman Ira ,Heyne Roy ,Hintz Susan R.
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منبع
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journal of perinatology - 2019 - دوره : 39 - شماره : 3 - صفحه:488 -496
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چکیده
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Objective(s)investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (cus) and near-term brain mri (ntmri), and bayley-iii scores in extremely preterm (ept) toddlers.study designcohort analysis of neonatal research network support neuro data. associations between brain abnormalities, hand function, and bayley-iii scores were examined using chi-square and generalized linear mixed effect model analyses.resultsa total of 433 children were included. sixteen percent had hand function deficits; these were associated with late cus (p < 0.001) abnormalities, white matter abnormality (wma) on ntmri (p < 0.001), and bayley-iii scores. six percent had cp. fourteen percent of children without and 50% of those with cp had hand function abnormalities.conclusionslate cus findings and severity of wma were significantly associated with hand function deficits. hand function deficits were nearly three times more common than cp and may be a useful marker of early brain insult and predictor of preterm birth effects on development.
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آدرس
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University of Texas Health Science Center at Houston, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, USA, Statistics and Epidemiology Unit, RTI International, USA, University of Texas Health Science Center at Houston, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, USA, Emory University, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, USA, University of Texas Southwestern Medical Center at Dallas, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, USA, Stanford University, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, USA
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Authors
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