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Genetic variants associated with patent ductus arteriosus in extremely preterm infants
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نویسنده
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Dagle John M. ,Ryckman Kelli K. ,Spracklen Cassandra N. ,Momany Allison M. ,Cotten C. Michael ,Levy Joshua ,Page Grier P. ,Bell Edward F. ,Carlo Waldemar A. ,Shankaran Seetha ,Goldberg Ronald N. ,Ehrenkranz Richard A. ,Tyson Jon E. ,Stoll Barbara J. ,Murray Jeffrey C.
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منبع
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journal of perinatology - 2019 - دوره : 39 - شماره : 3 - صفحه:401 -408
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چکیده
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Objective:patent ductus arteriosus (pda) is a commonly observed condition in preterm infants. prior studies have suggested a role for genetics in determining spontaneous ductal closure. using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with pda in extremely preterm infants.study design:preterm infants (n = 1013) enrolled at nichd neonatal research network sites were phenotyped for pda. dna was genotyped for 1634 single nucleotide polymorphisms (snps) from candidate genes. analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables.results:snps in several genes were associated with the clinical diagnosis of pda and with surgical ligation in extremely preterm neonates diagnosed with pda (p < 0.01). none of the associations were significant after correction for multiple comparisons.conclusion:we identified several common genetic variants associated with pda. these findings may inform further studies on genetic risk factors for pda in preterm infants.
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آدرس
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University of Iowa, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA, University of North Carolina, Department of Genetics, USA, University of Iowa, Department of Pediatrics, USA, Duke University, Department of Pediatrics, USA, Social, Statistical and Environmental Sciences Unit, USA, Social, Statistical and Environmental Sciences Unit, USA, University of Iowa, Department of Pediatrics, USA, University of Alabama at Birmingham, Department of Pediatrics, USA, Wayne State University, Department of Pediatrics, USA, Duke University, Department of Pediatrics, USA, Yale University School of Medicine, Department of Pediatrics, USA, University of Texas Medical School at Houston, Department of Pediatrics, USA, Emory University School of Medicine, Department of Pediatrics, USA, University of Iowa, Department of Pediatrics, USA
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Authors
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